张明珠，女，汉族，1990年10月出生，安徽安庆人，博士，中共党员，硕士生导师，同时担任安庆师范大学生命科学学院研究生辅导员及研究生党支部书记。于 2010 年考入安庆师范大学生物科学专业， 2014 年考入安徽大学生命科学学院，师从陈彦教授，从事天然产物食用菌多糖免疫调节活性研究，并于 2016 年通过硕博连读转安徽大学化学与化工学院，师从田玉鹏教授，主要从事小分子荧光探针的生物学功能应用研究。 2019 年博士毕业后就职于安庆师范大学专任教师岗位，主要从事小分子荧光探针诊疗应用和天然产物多糖的生物学功能应用研究以及师范生教学能力提升培养研究；作为指导教师，指导研究生参加互联网+，大学生创新创业年会等多项比赛；主持多项安徽省重点实验室基金，参与国家自然科学基金、安徽省重点教学研究项目。在 《Sens. Actuators B-Chem.》（中科院分区1区Top期刊）, 《Chem. Sci.》, 《Theranostics》, 《Inorg. Chem.》, 《Chem. Eng. J.》, J. Mater. Chem. B., 和 Int. J. Biol. Macromol等知名国际期刊上发表 SCI 论文 20 余篇；在CSCD核心期刊《植物学报》发表论文 1 篇；获得国家专利 3 项。

一、主讲课程

本科生：《生物化学》、《生物教学论》、《生化分离与分析技术》

研究生：《生物教育测量与评价》、《生物实验教学研究》

二、工作经历

2019.07— 至 今 安庆师范大学生命科学学院 讲师、研究生辅导员及党支部书记

三、荣获奖励

[1] 2020年 安庆师范大学第二届青年教师智慧课堂教学比赛 三等奖

[2] 2021年 第十四届全国大学生创新创业年会“优秀指导老师”

[3] 2022年 “省级研究生优秀辅导员”

四、学术研究课题

[1] 主持皖西南生物多样性研究与生态保护安徽省重点实验室基金(Wz2021003), 2021

[2] 主持皖西南生物多样性研究与生态保护安徽省重点实验室基金(Wsz202206), 2022

五、成果

1. 论文

[1] 张明珠, 秦华光, 穆丹, 杨龙宇, 李虎, 岂泽华, 王玉玺, 张永成, 叶利利, 殷文晶, 王树元, 饶玉春*, 吴彦*,茶多糖的抗氧化活性及对细胞氧化损伤的保护机制，植物学报2022, 57 (4): 444–456.

[2] Mingzhu Zhang, Yu Shen; Xu Cheng, Longyu Yang, Hu Li, Yupeng Tian, Xiaohe Tian*; Engineering a tumor-specific and mitochondria targeted fluorescent probe for modulated autophagy and exploited anti-cancer therapy, Sensors and Actuators: B. Chemical, 2022, 353 131178.

[3] 张明珠，穆丹，吴彦. 课程思政在师范专业生物化学教学中的实施路径探索. 科教文汇，2021, 53: 113-115.

[4] Mingzhu Zhang, Xiaohe Tian, Ya Wang, Dandan Wan, Wan Li, Lei Chen, Wenjun Pan, ShomailaMehmood, Yan Chen*, Immunomodulating activity of the polysaccharide TLH-3 from Tricholomalobayense in RAW264.7 macrophages. International Journal Biological Macromolecules 2018, 107, 2679–2685.

[5] Mingzhu Zhang, Wei Du, Xiaohe Tian, Ruilong Zhang, Meng Zhao, Hongping Zhou, Yaqi Ding, Lin Li, Jieying Wu, Yupeng Tian*, Real-time noninvasive monitoring cell mortality using a two-photon emissive probe based on quaternary ammonium, Journal of Materials Chemistry B 2018, 6, 4417–4421.

[6] Mingzhu Zhang, Rin Su, Qiong Zhang, Lei Hu, Xiaohe Tian， Yan Chen, Hongping Zhou, Jieying Wu, Yupeng Tian*, Ultra-bright intercellular lipids pseudo di-BODIPY probe with low molecular weight, high quantum yield and large two-photon action cross-sections, Sensors and Actuators B: Chemica 2018, 261, 161–168.

[7] Yingzhong Zhu†, Mingzhu Zhang†, Yupeng Tian, Xiaohe Tian*, NF-κB hijacking theranostic Pt(ІІ) complex: a new avenue in cancer therapy. Theranostics 2019, 9 (8), 2158–2166.

[8] Qiong Zhang#, Mingzhu Zhang#, Hui Wang, Xiaohe Tian, Wen Ma, Lei Luo, Jieying Wu, Hongping Zhou, Shengli Li, Yupeng Tian. A series of two-photon absorption organotin (IV) cyano carboxylatederivatives for targeting nuclear and visualization of anticancer activities. J. Inorg. Biochem. 2019, 192,1 - 6.

[9] Xiao Sun#, Mingzhu Zhang#, Ruohong Due, Xiaojia Zheng, Caiguo Tang, Yiqun Wu, Jiacai He, Wei Huang, Yuanyin Wang, Zhiyuan Zhang. A polyethyleneimine-driven self-assembled nanoplatform for fluorescence and MR dual-mode imaging guided cancer chemotherapy. Chem. Eng. J. 2018, 350, 69 - 78.

[10] Shuyi Chen#, Mingzhu Zhang#, Chuanzhen Zhu, Huanxuan Lu, Meng Zhao, Xiaohe Tian, Qiong Zhang, Senio Campos De Souza, Fang Rong, Hongping Zhou, Jieying Wu , Yupeng Tian. Rational design of two-photon absorbing dicyanomethylene-4H-chromene derivatives and their application in bioimaging. Dyes Pigments, 2018, 148, 429-436.

[11] Dandan Liu#, Mingzhu Zhang#, Wei Du, Lei Hu, Fei Li, Xiaohe Tian,* Aidong Wang, Qiong Zhang, Zhongping Zhang, Jieying Wu, and Yupeng Tian.A Series of Zn(II) Terpyridine-Based Nitrate Complexes as Two-Photon Fluorescent Probe for Identifying Apoptotic and Living Cells via Subcellular Immigration. Inorg. Chem. 2018, 57 (13), 7676 - 7683.

[12] Jiaxi Xu, Ting Hu, Mingzhu Zhang, Pei Feng, Xin Wang, Xu Cheng*, Rupei Tang. A sequentially responsive nanogel via Pt(IV) crosslinking for overcoming GSH-mediated platinum resistance. J. Colloid Interf. Sci. 2021,601 85–97

[13] Xiaohe Tian, Yingzhong Zhu, Mingzhu Zhang, Lei Luo, Jieying Wu, Hongping Zhou, Lijuan Guan, Giuseppe Battaglia, Yupeng Tian. Localization Matters: A Nuclear Targeting Two-Photon Absorption Iridium Complex Induced Intracellular Immigration and Dual-damage in Photon Dynamic Therapy. Chem. Commun. 2017, 53, 3303-3306.

[14] Yingzhong Zhu, Wei Du, Mingzhu Zhang, Ying Xu, Leilei Song, Qiong Zhang, Xiaohe Tian, Hongping zhou, Jieying Wu and Yupeng Tian. A series of water-soluble A–π–A typological indolium derivatives with two-photon properties for rapidly detecting HSO3-/SO32- in living cells, J. Mater. Chem. B, 2017, 5, 3862-3869.

[15] Xiaohe Tian, Yingzhong Zhu, Mingzhu Zhang, Jingyun Tan, Qiong Zhang, Xingyu Wang, Jiaxiang Yang, Hongping Zhou, Jieying Wu, Yupeng Tian. Mild acidic-enhanced mitochondrial-targeting by a neutral thiophene based terpyridine molecule with large two-photon action cross-section. Dyes and Pigments. 2017, 139, 431-439.

[16] Lei Hu, Hui Wang, Xin Xu, Mingzhu Zhang, Xiaohe Tian, Jieying Wu, Hongping Zhou, Jiaxiang Yang, Yupeng Tian. A small-molecule with large two-photon action cross-section serves as the membrane-permeable probe for live cells imaging and bacteria viability. Sens. Actuators B-Chem.2017, 241, 1082-1089.

[17] Rongting Guan, Ziqi Zhou, Mingzhu Zhang, Hui Liu, Wei Du, Xiaohe Tian, Qiong Zhang, Hongping Zhou, Jieying Wu and Yupeng Tian. Organotin(IV) carboxylate complexes containing polyether oxygen chains with two-photon bsorption in the near infrared region and their anticancer activity. Dyes and Pigments, 2018,158, 428–437.

[18] Dajun Wu, Bin Fang, Mingzhu Zhang, Wei Du, Jun Zhang, Xiaohe Tian, QiongZhang, Hongping Zhou, Jieying Wu, Yupeng Tian. D-A type phenanthridine derivatives with aggregation-induced enhanced emission and third-order nonlinear optical properties for bioimaging. Dyes and Pigments, 2018, 159, 142–150.

[19] ouble labelling of intracellular mitochondria and nucleolus using thiophene pyridium salt with high quantum yield as biosensor and its application in stimulated emission depletion nanoscopy. Anal. Chim. Acta. 2018, 1008, 82-89.

[20] Sajid Hussain, Wei Du, Mingzhu Zhang, Bin Fang, Guocui Zhang, Su Rina, Nan Keqiana, Qiong Zhang, Xiaohe Tian, Yan Chen, Yupeng Tian. A series of two-photon absorption pyridinium sulfonate inner salts targeting endoplasmic reticulum (ER), inducing cellular stress and mitochondria-mediated apoptosis in cancer cells. J. Mater. Chem. B, 2018, 6, 1943-1950.

[21] Yu Shen, Tao Shao, Bin Fang, Wei Du, Mingzhu Zhang, Jiejie Liu, Tianyan Liu, Xiaohe Tian, Qiong Zhang, Aidong Wang, Jiaxiang Yang, Jieying Wu and Yupeng Tian. Visualization of mitochondrial DNA in living cells with super-resolution microscopy using thiophene-based terpytridine Zn(II) complexes. Chem. Commun. 2018, 54, 11288 - 11291.

[22] Tian X, Liu T, Fang B, Wang A, Zhang M, Sajid H, Luo L, Zhang R, Zhang Q, Wu J, Giuseppe B, Li L, Zhang Z, Tian Y. NeuN-Specific Fluorescent Probe Revealing Neuronal Nuclei Protein and Nuclear Acids Association in Living Neurons under STED Nanoscopy. ACS Appl. Mater. Interfaces, 2018, 10, 31959 - 31964.

[23] Wei Du, Hui Wang, Yingzhong Zhu, Xiaohe Tian, Mingzhu Zhang, Qiong Zhang, Senio Campos De Souza, Aidong Wang, Hongping Zhou, Zhongping Zhang, Jieying Wu, and Yupeng Tian. Two-photon Fluorescent Terpyridine Derivatives Containing Quaternary Ammonium for Specific Recognizing Ribosome RNA in Living Cells. ACS Appl. Mater. Interfaces, 2017, 9, 31424 - 31432.

2. 授权专利：

[1] 田肖和; 张明珠; 沙基德•侯赛因; 祝英忠; 李飞; 李胜利; 吴杰颖; 周虹屏; 田玉鹏; 一种线粒体双光子荧光粘度探针及其制备方法, 2017-3-15, 中国, ZL 2016 1 0927295.6 (专利)

[2] 田肖和; 祝英忠; 张明珠; 罗坤; 吴杰颖; 田玉鹏; 周虹屏; 杨家祥; 李飞; 李胜利; 一种环金属铂配合物及其制备方法, 2016-5-31, 中国, ZL 2016 1 0389730.4(专利)

[3] 田肖和; 祝英忠; 张明珠; 吴杰颖; 田玉鹏; 周虹屏; 杨家祥; 李胜利; 一种具有双重光动力治疗效果的光敏剂及其制备方法, 2016-12-20, 中国, ZL 2016 1N1181323.0(专利)